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5c–d). CX-5461-mediated S33 phosphorylation of RPA was independent of your mobile cycle stage and wasn't restricted to your nucleoli in HR-deficient cells. As a result, the formation of ssDNA buildings in CX-5461 handled cells can result in replication fork stalling and ATR activation with HRD exacerbating CX-5461-mediated replication worry whi